Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs

Abstract Early lung cancer screening by computed tomography is hampered by pulmonary nodules caused by massive COVID‐19 infections, necessitating an ultrasensitive approach for the early diagnosis of lung cancers at the single‐base level from circular tumor DNAs (ctDNAs). This study introduces an approach that merges DNA origami and DNA scissors technologies in a framework of surface plasmon resonance (SPR) biosensors. By combining the precision of DNA origami probes with the inherent single‐base resolution of DNA scissors, this method systematically addresses the limitations of conventional SPR techniques, resulting in enhanced detection accuracy. The synergistic interplay between DNA scissors and DNA origami…

• NN
  National Natural Science Foundation of China

  Awards: 62275164, U21A20511, 82001967
• NS
  Natural Science Foundation of Guangdong Province

  Award: 2021A1515011916
• DO
  Department of Education of Guangdong Province

  Award: 2022ZDZX1023
• SK
  State Key Laboratory of Luminescence and Applications

  Award: SKLA‐2020‐03