Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralization method, and sol-gel method. Subsequently, we elucidate the catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like activities), oxidase (OXD)-like…

• NS
  Natural Science Foundation of Shandong Province

  Award: ZR2023QB045
• TS
  Taishan Scholar Project of Shandong Province

  Award: tsqnz20230608
• QU
  Qingdao University

  Awards: DC2200000953, RZ2300002607
• NS
  Natural Science Foundation of Qingdao

  Award: 23-2-1-30-zyyd-jch