Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults

Llano, Luis Pérez de; Scélo, Ghislaine; Tran, Trung N.; Le, Tham; Fagerås, Malin; Cosío, Borja G.; Peters, Matthew; Pfeffer, Paul; Al‐Ahmad, Mona; Al‐Lehebi, Riyad; Altraja, Alan; Bergeron, Céline; Bjermer, Leif; Bjerrum, Anne Sofie; Bulathsinhala, Lakmini; Busby, John; Rosales, Diana Jimena Cano; Canonica, Giorgio Walter; Carter, Victoria; Charriot, Jérémy; Christoff, George; Denton, Eve; Dorscheid, Delbert R.; Sánchez, María José Fernández; Fonseca, João; Gibson, Peter G.; Goh, Celine; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Iwanaga, Takashi; Katial, Rohit; Koh, Mariko Siyue; Kuna, Piotr; Larenas‐Linnemann, Désirée; Lehtimäki, Lauri; Mahboub, Bassam; Martin, Neil; Matsumoto, Hisako; Menzies‐Gow, Andrew; Papadopoulos, Nikolaos G.; Popov, Todor A.; Porsbjerg, Celeste; Patel, Pujan; Rhee, Chin Kook; Sadatsafavi, Mohsen; Taillé, Camille; Torres‐Duque, Carlos A.; Tsai, Ming‐Ju; Ulrik, Charlotte Suppli; Upham, John W.; Bülow, Anna von; Wang, Eileen; Wechsler, Michael E.; Price, David

doi:10.1164/rccm.202311-2192oc

articleAmerican Journal of Respiratory and Critical Care MedicineMay 3, 2024HYBRID OA

Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults

LPLuis Pérez de Llano GSGhislaine Scélo TNTrung N. Tran TLTham Le MFMalin Fagerås

Hospital Universitario Lucus Augusti · Observational & Pragmatic Research Institute · +74 more institutions

PubMed

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Abstract

Abstract Rationale There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving remission that may be used to predict it. Methods This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry. Four asthma outcome domains were assessed in the 1 year before and after biologic initiation. A priori–defined remission cutoffs were: 0…

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Keywords

Medicine
Asthma
Intensive care medicine
MEDLINE
Pediatrics
Internal medicine

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