A Vacancy‐Engineering Ferroelectric Nanomedicine for Cuproptosis/Apoptosis Co‐Activated Immunotherapy
Harbin Engineering University · Chinese Academy of Sciences · +3 more institutions
Abstract
Abstract Low efficacy of immunotherapy due to the poor immunogenicity of most tumors and their insufficient infiltration by immune cells highlights the importance of inducing immunogenic cell death and activating immune system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed and engineered for ferroelectricity‐enhanced apoptosis, cuproptosis, and the subsequently evoked immunotherapy. In this structure, the suppressed recombination of the electron–hole pairs by the vacancies and the band bending by the ferroelectric polarization lead to high catalytic activity, triggering reactive oxygen species bursts…
Citation impact
- FWCI
- 24.04
- Percentile
- 100%
- References
- 67
Authors
10- YDYaqian Du
Harbin Engineering University
- XZXudong Zhao
Harbin Engineering University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- FHFei HeCorresponding
Harbin Engineering University
- HGHaijiang Gong
Harbin Engineering University
- JYJiani Yang
Harbin Medical University, Third Affiliated Hospital of Harbin Medical University
Topics & keywords
- Materials science
- Nanomedicine
- Ferroelectricity
- Immunotherapy
- Vacancy defect
- Apoptosis
- Nanotechnology
- Condensed matter physics