reviewJournal of Cell ScienceMay 1, 2024HYBRID OA

A short guide to the tight junction

SCSandra CitiMFMichael FrommMFMikio FuruseLGLorenza González‐MariscalANAsma Nusrat

University of Geneva · Charité - Universitätsmedizin Berlin · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Tight junctions (TJs) are specialized regions of contact between cells of epithelial and endothelial tissues that form selective semipermeable paracellular barriers that establish and maintain body compartments with different fluid compositions. As such, the formation of TJs represents a critical step in metazoan evolution, allowing the formation of multicompartmental organisms and true, barrier-forming epithelia and endothelia. In the six decades that have passed since the first observations of TJs by transmission electron microscopy, much progress has been made in understanding the structure, function, molecular composition and regulation of TJs. The goal of this Perspective is to highlight the key concepts…

Citation impact

115
total citations
FWCI
25.60
Percentile
100%
References
113
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Biology
  • Tight junction
  • Paracellular transport
  • Cell biology
  • Function (biology)
  • Claudin
  • Membrane
  • Genetics
No related works found for this paper.

Funding