Fecal microbiota transplantation: current challenges and future landscapes

SUMMARY Given the importance of gut microbial homeostasis in maintaining health, there has been considerable interest in developing innovative therapeutic strategies for restoring gut microbiota. One such approach, fecal microbiota transplantation (FMT), is the main “whole gut microbiome replacement” strategy and has been integrated into clinical practice guidelines for treating recurrent Clostridioides difficile infection (rCDI). Furthermore, the potential application of FMT in other indications such as inflammatory bowel disease (IBD), metabolic syndrome, and solid tumor malignancies is an area of intense interest and active research. However, the complex and variable nature of FMT makes it challenging to…

• AH
  Alberta Health Services
• UO
  University of Alberta
• NI
  National Institute for Health and Care Research
• CF
  Cystic Fibrosis Trust
• UO
  University of Nottingham
• CI
  Canadian Institutes of Health Research

  Award: PJT168954
• MR
  Medical Research Council

  Award: MR/S019103/1
• NN
  NIHR Nottingham Biomedical Research Centre