articleCellMay 1, 2024HYBRID OA

Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

CWChen WangQZQun ZengZMZeynep Melis GülSWSisi WangRPRobert Pick

University of Geneva · Harvard University · +11 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

T cells, are important parameters for the control of tumor growth and response to immunotherapy. Here, we show in murine and human cancers that these parameters exhibit circadian oscillations, driven by both the endogenous circadian clock of leukocytes and rhythmic leukocyte infiltration, which depends on the circadian clock of endothelial cells in the tumor microenvironment. To harness these rhythms therapeutically, we demonstrate that efficacy of chimeric antigen receptor T cell therapy and immune checkpoint blockade can be improved by adjusting the time of treatment during the day. Furthermore, time-of-day-dependent T cell signatures in murine tumor models predict overall survival in patients with melanoma…

Citation impact

182
total citations
FWCI
44.76
Percentile
100%
References
66
Citations per year

Authors

27

Topics & keywords

Topics
Keywords
  • Biology
  • Circadian rhythm
  • Immunotherapy
  • Tumor microenvironment
  • CD8
  • Immune system
  • Immunology
  • Melanoma
UN Sustainable Development Goals
  • Good health and well-being
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