Aging clocks based on accumulating stochastic variation
University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · +1 more institution
Abstract
Aging clocks have provided one of the most important recent breakthroughs in the biology of aging, and may provide indicators for the effectiveness of interventions in the aging process and preventive treatments for age-related diseases. The reproducibility of accurate aging clocks has reinvigorated the debate on whether a programmed process underlies aging. Here we show that accumulating stochastic variation in purely simulated data is sufficient to build aging clocks, and that first-generation and second-generation aging clocks are compatible with the accumulation of stochastic variation in DNA methylation or transcriptomic data. We find that accumulating stochastic variation is sufficient to predict…
Citation impact
- FWCI
- 22.16
- Percentile
- 100%
- References
- 99
Authors
2- DHDavid H. MeyerCorresponding
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
- BSBjörn Schumacher
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
Topics & keywords
- Variation (astronomy)
- Evolutionary biology
- Biology
- Physics
- Astronomy
- Good health and well-being