Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to…

• NN
  National Natural Science Foundation of China

  Awards: 2021YFA1101401, 82271451, U21A20358, 82325018
• NS
  Natural Science Foundation of Fujian Province

  Award: 2021J02004
• NK
  National Key Research and Development Program of China

  Awards: 2021YFA1101401, 2021ZD0202402
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2021B1515120081