Expanded ROS Generation and Hypoxia Reversal: Excipient‐free Self‐assembled Nanotheranostics for Enhanced Cancer Photodynamic Immunotherapy
Army Medical University · Southwest Hospital · +4 more institutions
Abstract
The efficacy of photodynamic therapy (PDT)-related cancer therapies is significantly restricted by two irreconcilable obstacles, i.e., low reactive oxygen species (ROS) generation capability and hypoxia which constrains the immune response. Herein, this work develops a self-assembled clinical photosensitizer indocyanine green (ICG) and the HSP90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) nanoparticles (ISDN) without any excipient. This work discovers that the hydrophobic interaction forces between ICG and 17-DMAG promote the photostability of ICG and its intersystem crossing (ISC) process, thereby improving the ROS quantum yield from 0.112 to 0.46. Augmented ROS generation enhances…
Citation impact
- FWCI
- 18.79
- Percentile
- 100%
- References
- 64
Authors
10- JYJing Yang
Army Medical University, Southwest Hospital
- BRBibo Ren
Army Medical University, Sichuan University, Southwest Hospital
- XYXuntao Yin
Guangzhou Women and Children Medical Center, Guangzhou Medical University
- LXLunli Xiang
Army Medical University, Southwest Hospital
- YHYanQiu Hua
Army Medical University, Southwest Hospital
Topics & keywords
- Photodynamic therapy
- Cancer research
- Tumor microenvironment
- Photosensitizer
- Indocyanine green
- Reactive oxygen species
- Cancer cell
- Immunogenic cell death