GPR41 and GPR43: From development to metabolic regulation
Chungnam National University · Boryung Pharma (South Korea) · +1 more institution
Abstract
G-protein-coupled receptors are a diverse class of cell surface receptors that orchestrate numerous physiological functions. The G-protein-coupled receptors, GPR41 and GPR43, sense short-chain fatty acids (SCFAs), which are metabolites of dietary fermentation by the host's intestinal bacteria. These receptors have gained attention as potential therapeutic targets against various diseases because of their SCFA-mediated beneficial effects on the host's intestinal health. Mounting evidence has associated the activity of these receptors with chronic metabolic diseases, including obesity, diabetes, inflammation, and cardiovascular disease. However, despite intensive research using various strategies, including gene…
Citation impact
- FWCI
- 34.92
- Percentile
- 100%
- References
- 102
Authors
3Topics & keywords
- Receptor
- Biology
- Disease
- Gut flora
- Psychological intervention
- Inflammation
- Computational biology
- Knockout mouse