Brain clearance is reduced during sleep and anesthesia
UK Dementia Research Institute · Imperial College London · +3 more institutions
Indexed incrossrefpubmed
Abstract
It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
Citation impact
134
total citations
- FWCI
- 32.65
- Percentile
- 100%
- References
- 36
Citations per year
Authors
9Topics & keywords
Topics
Keywords
- Sleep (system call)
- Anesthesia
- Neuroscience
- Anesthetic
- Medicine
- Rapid eye movement sleep
- Psychology
- Eye movement
No related works found for this paper.
Funding
- WWellcomeAwards: 220759/Z/20/Z, 104931/Z/14/Z
- WTWellcome TrustAwards: 104931/Z/14/Z, 104931, 220759/Z/20/Z
- ICImperial College LondonAward: 104931/Z/14/Z
- UDUK Dementia Research InstituteAward: UK DRI-5004
- MRMedical Research Council
- EAEngineering and Physical Sciences Research Council
- BABiotechnology and Biological Sciences Research CouncilAward: BB/L105129/1