articleNature MedicineMay 13, 2024HYBRID OA

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

YZYue ZengCHChunhong HuYLYizheng LiJZJiansong ZhouSWShuxing Wang

Central South University · Second Xiangya Hospital of Central South University · +8 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but few clinical studies have explored its relationship with response to immune checkpoint inhibitors (ICIs). Here we report results from cohort 1 of the prospective observational STRESS-LUNG study, which investigated the association between ED and clinical efficacy of first-line treatment of ICIs in patients with advanced non-small-cell lung cancer. ED was assessed by Patient Health Questionnaire-9 and Generalized Anxiety Disorder 7-item scale. The study included 227 patients with 111 (48.9%) exhibiting ED who…

Citation impact

110
total citations
FWCI
37.08
Percentile
100%
References
87
Citations per year

Authors

29

Topics & keywords

Topics
Keywords
  • Lung cancer
  • Immune system
  • Medicine
  • Cancer
  • Oncology
  • Immunology
  • Distress
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding