Ultrasound‐Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration

Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)-triggered electrical stimulation (ES) and controllable drug release for repairing peripheral nerve injury are proposed. The inner layer of the NGCs is the barium titanate piezoelectric nanoparticles (BTNPs)-doped polyvinylidene fluoride-trifluoroethylene [BTNPs/P(VDF-TrFE)] electrospinning nanofibers with improved piezoelectricity and aligned orientation. The outer side…

• NN
  National Natural Science Foundation of China

  Awards: 92149304, 52073060, 22002018, 82030029, 22302231, 82330033
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20232007
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2021YFS0371
• NK
  National Key Research and Development Program of China

  Awards: 2020YFB1313100, 2021YFA1101800, 2021YFA1101300, 2020YFA0112503