Precise modulation and use of reactive oxygen species for immunotherapy
Center for Life Sciences · Tsinghua University · +3 more institutions
Abstract
Reactive oxygen species (ROS) play an important role in regulating the immune system by affecting pathogens, cancer cells, and immune cells. Recent advances in biomaterials have leveraged this mechanism to precisely modulate ROS levels in target tissues for improving the effectiveness of immunotherapies in infectious diseases, cancer, and autoimmune diseases. Moreover, ROS-responsive biomaterials can trigger the release of immunotherapeutics and provide tunable release kinetics, which can further boost their efficacy. This review will discuss the latest biomaterial-based approaches for both precise modulation of ROS levels and using ROS as a stimulus to control the release kinetics of immunotherapeutics.…
Citation impact
- FWCI
- 17.87
- Percentile
- 100%
- References
- 176
Authors
10- XLXinyan LiCorresponding
Center for Life Sciences, Tsinghua University
- JGJingjing GaoCorresponding
Brigham and Women's Hospital, Harvard University, University of Massachusetts Amherst
- CWChengcheng Wu
Center for Life Sciences, Tsinghua University
- CWChaoyu Wang
Center for Life Sciences, Tsinghua University
- RZRuoshi Zhang
Center for Life Sciences, Tsinghua University
Topics & keywords
- Reactive oxygen species
- Immunotherapy
- Cancer immunotherapy
- Immune system
- Immune modulation
- Cancer research
- Biology
- Immunology