Regulatory mechanisms of PD-1/PD-L1 in cancers

Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) and programmed cell death ligands (PD-Ls) are considered to be the major immune checkpoint molecules. The interaction of PD-1 and PD-L1 negatively regulates adaptive immune response mainly by inhibiting the activity of effector T cells while enhancing the function of immunosuppressive regulatory T cells (Tregs), largely contributing to the maintenance of immune homeostasis that prevents dysregulated immunity and harmful immune responses. However, cancer cells exploit the PD-1/PD-L1 axis to cause…

• BX
  Beijing Xisike Clinical Oncology Research Foundation
• NN
  National Natural Science Foundation of China

  Awards: 82272631, 82173339, U23A20456, 82072596, U23A20456, 82272631, 82072596, 82173339, 111-2-12
• CS
  Central South University

  Award: 111-2-12
• NS
  Natural Science Foundation of Hainan Province

  Award: 2024JJ3036