Neutrophils in Cancer immunotherapy: friends or foes?
Yangtze University · University of Hradec Králové · +4 more institutions
Abstract
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix metalloproteinase 9, within the tumor microenvironment. They also modulate the expression of tumor necrosis factor-related apoptosis-inducing ligand and Fas ligand, augmenting their capacity to induce tumor cell apoptosis. Their involvement in antitumor immune regulation synergistically activates a network of immune cells, bolstering anticancer effects. Paradoxically, neutrophils can succumb to the influence of tumors, triggering signaling cascades such as JAK/STAT, which deactivate the immune system…
Citation impact
- FWCI
- 32.86
- Percentile
- 100%
- References
- 180
Authors
8Topics & keywords
- Tumor microenvironment
- Immune system
- Angiogenesis
- Biology
- Cancer research
- Immunotherapy
- Immunology
- Cancer
- Good health and well-being