Abstract
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are driven by time, irrespective of the precise causes, can be confronted with the idea that aging and cancer share common mechanistic grounds that are referred to as 'hallmarks'. Indeed, several hallmarks of aging also contribute to carcinogenesis and tumor progression, but some of the molecular and cellular characteristics of aging may also reduce the probability of developing lethal cancer, perhaps explaining why very old age (> 90 years) is accompanied by a reduced incidence of neoplastic diseases. We will also discuss the possibility that the aging process itself…
Citation impact
- FWCI
- 46.66
- Percentile
- 100%
- References
- 149
Authors
3- LMLéa MontégutCorresponding
Inserm, Université Paris Cité, Institut Gustave Roussy, Sorbonne Université, Centre de Recherche des Cordeliers
- CLCarlos López-Otı́n
Inserm, Université Paris Cité, Universidad Nebrija, Sorbonne Université, Centre de Recherche des Cordeliers
- GKGuido Kroemer
Inserm, Université Paris Cité, Institut Gustave Roussy, Sorbonne Université, Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen
Topics & keywords
- Cancer
- Carcinogenesis
- Disease
- Crosstalk
- Biology
- Ageing
- Bioinformatics
- Medicine
- Good health and well-being