Antibody-displaying extracellular vesicles for targeted cancer therapy
Karolinska University Hospital · Karolinska Institutet · +5 more institutions
Abstract
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological signals across tissues. Here, by leveraging these functionalities, we show that EVs decorated with an antibody-binding moiety specific for the fragment crystallizable (Fc) domain can be used as a modular delivery system for targeted cancer therapy. The Fc-EVs can be decorated with different types of immunoglobulin G antibody and thus be targeted to virtually any tissue of interest. Following optimization of the engineered EVs by screening Fc-binding and EV-sorting moieties, we show the targeting of EVs to cancer cells displaying the human epidermal receptor 2 or the programmed-death ligand 1, as well as lower tumour…
Citation impact
- FWCI
- 24.39
- Percentile
- 100%
- References
- 54
Authors
22- OPOscar P. B. WiklanderCorresponding
Karolinska University Hospital, Karolinska Institutet
- DRDoste R. Mamand
Karolinska University Hospital, Karolinska Institutet
- MHMohammad H. Forouzanfar
Karolinska Institutet, Salahaddin University-Erbil
- WZWenyi Zheng
Karolinska University Hospital, Karolinska Institutet
- RJRim Jawad Wiklander
Karolinska University Hospital, Karolinska Institutet
Topics & keywords
- Extracellular vesicles
- Antibody
- Cancer therapy
- Cancer
- Extracellular
- Immunology
- Cancer research
- Medicine
- Good health and well-being