Metabolic Recoding of NSUN2‐Mediated m 5 C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m 5 C‐ENO1 Positive Feedback Loop

Abstract The RNA modification, 5‐methylcytosine (m 5 C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes. However, the exact mechanisms governing m 5 C modifications during the onset and progression of colorectal cancer (CRC) remain unclear. Here, it is determined that the m 5 C methyltransferase NSUN2 exhibits significantly elevated expression and exerts an oncogenic function in CRC. Mechanistically, NSUN2 and YBX1 are identified as the “writer” and “reader” of ENO1, culminating in the reprogramming of the glucose metabolism and increased production of lactic acid in an m 5 C‐dependent manner. The…

• HC
  Health Commission of Hubei Province
• WU
  Wuhan University
• ZH
  Zhongnan Hospital of Wuhan University