Electrochemical protein biosensors for disease marker detection: progress and opportunities
Wuhan National Laboratory for Optoelectronics · Anhui University · +3 more institutions
Abstract
The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody-antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve…
Citation impact
- FWCI
- 24.48
- Percentile
- 100%
- References
- 126
Authors
8Topics & keywords
- Biosensor
- Nanotechnology
- Aptamer
- Protein detection
- Materials science
- Computer science
- Biology
- Molecular biology