Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective
University of the Basque Country · Instituto de Salud Carlos III · +3 more institutions
Abstract
Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, the recognition of the immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores the wound healing process, highlighting the engagement of the immune system, and delving into the behaviors of innate and adaptive immune cells in chronic wound scenarios. Moreover, the article investigates biomaterial-based strategies for the modulation of the immune system, elucidating how the adjustment of their…
Citation impact
- FWCI
- 26.23
- Percentile
- 100%
- References
- 273
Authors
6- KLKevin Las Heras
University of the Basque Country
- IGItxaso García-Orue
Instituto de Salud Carlos III, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, University of the Basque Country
- FRFiorenza Rancan
Clinical Research Center for Hair and Skin Science, Charité - Universitätsmedizin Berlin
- MIManoli Igartúa
University of the Basque Country, Instituto de Salud Carlos III, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
- ESEdorta Santos‐VizcaínoCorresponding
University of the Basque Country, Instituto de Salud Carlos III, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
Topics & keywords
- Immune system
- Nanocarriers
- Wound healing
- Regenerative medicine
- Medicine
- Mesenchymal stem cell
- Stromal cell
- Acquired immune system