Autoantibodies Targeting Nephrin in Podocytopathies
Johns Hopkins University · Inserm · +6 more institutions
Abstract
Minimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome in children, are immune-mediated podocytopathies that lead to nephrotic syndrome. Autoantibodies targeting nephrin have been found in patients with minimal change disease, but their clinical and pathophysiological roles are unclear.
We conducted a multicenter study to analyze antinephrin autoantibodies in adults with glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy, antineutrophil cytoplasmic antibody-associated glomerulonephritis, and lupus nephritis, as well as in children with idiopathic nephrotic syndrome and in controls. We also created an experimental mouse model through active immunization with recombinant murine nephrin.
Citation impact
- FWCI
- 68.25
- Percentile
- 100%
- References
- 27
Authors
35- FEFelicitas E. HengelCorresponding
Johns Hopkins University, Inserm, Universität Hamburg, Heidelberg University, University Hospital Heidelberg, Sorbonne Université, Mahindra and Mahindra Limited (India), University Medical Center Hamburg-Eppendorf
- SDSilke Dehde
Johns Hopkins University, Inserm, Universität Hamburg, Heidelberg University, University Hospital Heidelberg, Sorbonne Université, Mahindra and Mahindra Limited (India), University Medical Center Hamburg-Eppendorf
- MLMoritz Lassé
Johns Hopkins University, Inserm, Universität Hamburg, Heidelberg University, University Hospital Heidelberg, Sorbonne Université, Mahindra and Mahindra Limited (India), University Medical Center Hamburg-Eppendorf
- GZGunther Zahner
Johns Hopkins University, Inserm, Universität Hamburg, Heidelberg University, University Hospital Heidelberg, Sorbonne Université, Mahindra and Mahindra Limited (India), University Medical Center Hamburg-Eppendorf
- LSLarissa Seifert
Johns Hopkins University, Inserm, Universität Hamburg, Heidelberg University, University Hospital Heidelberg, Sorbonne Université, Mahindra and Mahindra Limited (India), University Medical Center Hamburg-Eppendorf
Topics & keywords
- Autoantibody
- Nephrin
- Medicine
- Immunology
- Antibody
- Internal medicine
- Zero hunger
Funding
- DFDeutsche ForschungsgemeinschaftAwards: HU 1016/ 12-1, HU 1016/11-1, KR 1984/4-1, HU 1016/8-2
- BFBundesministerium für Bildung und ForschungAwards: STOP-FSGS- 01GM2202A, UPTAKE- 01EK2105D, NephrESA-031L0191E
- EKElse Kröner-Fresenius-StiftungAwards: 2021_EKFK.15, 2019_KollegSE.04
- ELEva Luise und Horst Köhler StiftungAward: 2019_KollegSE.04
- NNNovo Nordisk FondenAward: NNF19OC0056043