Hormone Regulation in Testicular Development and Function

The testes serve as the primary source of androgens and the site of spermatogenesis, with their development and function governed by hormonal actions via endocrine and paracrine pathways. Male fertility hinges on the availability of testosterone, a cornerstone of spermatogenesis, while follicle-stimulating hormone (FSH) signaling is indispensable for the proliferation, differentiation, and proper functioning of Sertoli and germ cells. This review covers the research on how androgens, FSH, and other hormones support processes crucial for male fertility in the testis and reproductive tract. These hormones are regulated by the hypothalamic-pituitary-gonad (HPG) axis, which is either quiescent or activated at…

• NN
  National Natural Science Foundation of China

  Awards: 82071634, 32170865, U22A20277, 32170865, and 82071634, U22A20277
• NS
  Natural Science Foundation of Guangdong Province

  Awards: 82071634, 202103030003, 2022B1111080007, 2022A1515012178, U22A20277, 32170865