SGLT2 inhibition eliminates senescent cells and alleviates pathological aging
Juntendo University · Niigata University · +5 more institutions
Abstract
It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium-glucose co-transporter 2 (SGLT2) enhances clearance of senescent cells, thereby ameliorating age-associated phenotypic changes. In a mouse model of dietary obesity, short-term treatment with the SGLT2 inhibitor canagliflozin reduced the senescence load in visceral adipose tissue and improved adipose tissue inflammation and metabolic dysfunction, but normalization of plasma glucose by insulin treatment had no effect on senescent cells. Canagliflozin extended the…
Citation impact
- FWCI
- 36.69
- Percentile
- 100%
- References
- 42
Authors
13Topics & keywords
- Canagliflozin
- Adipose tissue
- Senescence
- Inflammation
- Downregulation and upregulation
- Autophagy
- Endocrinology
- Chemistry
- Good health and well-being
Funding
- JAJapan Agency for Medical Research and DevelopmentAwards: JP20gm1110012, 21zf0127003s0201, CREST, JP20ek0210114, JP21zf0127001
- MOMinistry of Education, Culture, Sports, Science and TechnologyAwards: 22K18389, 19K07316, 23H05487, JP21zf0127001, CREST
- OMOno Medical Research Foundation
- JSJapan Society for the Promotion of ScienceAwards: 23H05487, 22K18389, JPJSA3F20230001, 19K07316, CREST, JP21zf0127001
- CRCore Research for Evolutional Science and TechnologyAward: JPMJCR2123
- MRMoonshot Research and Development ProgramAward: 21zf0127003s0201