reviewRedox BiologyMay 30, 2024GOLD OA

Ferroptosis in health and disease

CBCarsten BerndtHAHamed AlborziniaVSVera Skafar AmenSAScott AytonUBUladzimir Barayeu

Heinrich Heine University Düsseldorf · German Cancer Research Center · +56 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising…

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286
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94

Topics & keywords

Topics
Keywords
  • Disease
  • GPX4
  • Programmed cell death
  • Biology
  • Neuroscience
  • Medicine
  • Apoptosis
  • Oxidative stress
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