Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling
South China Agricultural University · Nanjing Agricultural University · +2 more institutions
Abstract
Engineering natural microbiomes for biotechnological applications remains challenging, as metabolic interactions within microbiomes are largely unknown, and practical principles and tools for microbiome engineering are still lacking. Here, we present a combinatory top-down and bottom-up framework to engineer natural microbiomes for the construction of function-enhanced synthetic microbiomes. We show that application of herbicide and herbicide-degrader inoculation drives a convergent succession of different natural microbiomes toward functional microbiomes (e.g., enhanced bioremediation of herbicide-contaminated soils). We develop a metabolic modeling pipeline, SuperCC, that can be used to document metabolic…
Citation impact
- FWCI
- 38.81
- Percentile
- 100%
- References
- 126
Authors
13- ZRZhepu Ruan
South China Agricultural University, Nanjing Agricultural University, Ministry of Agriculture and Rural Affairs
- KCKai Chen
Nanjing Agricultural University, Ministry of Agriculture and Rural Affairs
- WCWeimiao Cao
Nanjing Agricultural University, Ministry of Agriculture and Rural Affairs
- LMLei Meng
Nanjing Agricultural University, Ministry of Agriculture and Rural Affairs
- BYBingang Yang
Nanjing Agricultural University, Ministry of Agriculture and Rural Affairs
Topics & keywords
- Microbiome
- Bioremediation
- Function (biology)
- Biology
- Computational biology
- Biochemical engineering
- Ecology
- Bioinformatics