Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing

Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic process in wound healing requires both the generation of ROS to inhibit bacteria and the subsequent reduction of ROS levels to initiate and promote tissue regeneration, which calls for a more intelligent ROS regulation dressing system. Hence, a dual-layered hydrogel (Dual-Gel) tailored to the process of burn wound repair is designed: the inner layer hydrogel (Gel 2) first responds to bacterial hyaluronidase (Hyal) to deliver aggregation-induced emission photosensitizer functionalized adipose-derived stem cell nanovesicles, which generate ROS…

• NN
  National Natural Science Foundation of China

  Awards: 82102256, 82322042, 81972019, 82102444, 82272248
• CP
  China Postdoctoral Science Foundation

  Award: 2021M693638
• NK
  National Key Research and Development Program of China

  Award: 2021YFC2302200
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2021B1515120036, 2023A1515012375