Colorimetric sensing for translational applications: from colorants to mechanisms

, lateral flow devices, microfluidic paper-based analytical devices, and wearable sensing devices. Two highlighted colorimetric formats are discussed: combinational and activatable systems based on the sensor-array and lock-and-key mechanisms, respectively. Case discussions in colorimetric assays are organized by the analyte identities. Finally, the review presents challenges and perspectives for the design and development of colorimetric detection schemes as well as applications. The goal of this review is to provide a foundational resource for developing colorimetric systems and underscoring the colorants and mechanisms that facilitate the continuing evolution of POC sensors.

• NS
  National Science Foundation

  Awards: CBET-2335597, DMR-2242375
• NI
  National Institutes of Health

  Awards: R21 AG065776-S1, R21 AI157957, R01 DE031114