Pathology of pain and its implications for therapeutic interventions

Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessment and treatment fall short of clinical needs. Benefiting from advances in neuroscience and biotechnology, the neuronal circuits and molecular mechanisms critically involved in pain modulation have been elucidated. These research achievements have incited progress in identifying new diagnostic and therapeutic targets. In this review, we first introduce fundamental knowledge about pain, setting the stage for the subsequent contents. The review next delves into the molecular…

• NN
  National Natural Science Foundation of China

  Awards: 82273231, 81974166, 31872774, 2017YFA0701302, 82073192, 81773135, 32171002
• PU
  Peking University
• NK
  National Key Research and Development Program of China

  Awards: 2019YFB1311505, 2017YFA0701302