reviewJournal of Hematology & OncologyJun 11, 2024GOLD OA

Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

BTBelén ToledoLZLinrui Zhu ChenMPMaría Paniagua-SanchoJAJuan Antonio MarchalMPMacarena Perán

Universidad de Jaén · Cancer Center Amsterdam · +6 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles in tumour growth, angiogenesis, immune regulation, metastasis, and chemoresistance. TAMs encompass various subpopulations, primarily classified into M1 and M2 subtypes based on their differentiation and activities. M1 macrophages, characterized by a pro-inflammatory phenotype, exert anti-tumoural effects, while M2 macrophages, with an anti-inflammatory phenotype, function as protumoural regulators. These highly versatile cells respond to stimuli from tumour cells and other constituents within the tumour microenvironment…

Citation impact

184
total citations
FWCI
39.53
Percentile
100%
References
366
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Immune system
  • Macrophage polarization
  • Phenotype
  • Chemokine
  • Macrophage
  • Cancer research
  • Angiogenesis
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding