An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair

Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, and lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing and inherent antibacterial activity based on ε-polylysine and a poly(ethylene glycol) derivative is developed. The engineered hydrogel exhibits rapid gelation behavior, high mechanical strength, strong adhesion to various tissues, and can sustain an ultrahigh burst pressure of 450 mmHg. It also presents excellent biocompatibility, biodegradability, antibacterial properties,…

• NN
  National Natural Science Foundation of China

  Awards: 21935011, 21725403
• ST
  Science, Technology and Innovation Commission of Shenzhen Municipality

  Awards: JCYJ20220818100601003, KQTD20200820113012029, JCYJ20190814114605162
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2022A1515110321, 2024A1515011621