RCSB protein Data Bank: exploring protein 3D similarities via comprehensive structural alignments
San Diego Supercomputer Center · Rutgers, The State University of New Jersey
Abstract
MOTIVATION: Tools for pairwise alignments between 3D structures of proteins are of fundamental importance for structural biology and bioinformatics, enabling visual exploration of evolutionary and functional relationships. However, the absence of a user-friendly, browser-based tool for creating alignments and visualizing them at both 1D sequence and 3D structural levels makes this process unnecessarily cumbersome. RESULTS: We introduce a novel pairwise structure alignment tool (rcsb.org/alignment) that seamlessly integrates into the RCSB Protein Data Bank (RCSB PDB) research-focused RCSB.org web portal. Our tool and its underlying application programming interface (alignment.rcsb.org) empowers users to align…
Citation impact
- FWCI
- 38.20
- Percentile
- 100%
- References
- 20
Authors
5Topics & keywords
- Protein Data Bank (RCSB PDB)
- Protein Data Bank
- Computer science
- Structural bioinformatics
- Sequence alignment
- Interface (matter)
- Visualization
- Structural alignment
Funding
- NSNational Science FoundationAwards: 2129634, DBI-2321666, 2321666, DBI-2129634, DE-SC0019749, 2019297, DBI-2019297
- UDU.S. Department of EnergyAward: DE-SC0019749
- NINational Institutes of HealthAward: R01GM133198
- DFDirectorate for Biological SciencesAward: DBI-2321666
- NCNational Cancer InstituteAward: R01GM133198
- NINational Institute of General Medical SciencesAward: R01GM133198
- NINational Institute of Allergy and Infectious DiseasesAward: R01GM133198