Roles of H3K4 methylation in biology and disease
Peking University · Peking University Cancer Hospital · +2 more institutions
Abstract
Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease. In this review, we focus on recent studies that have yielded insights into how levels and patterns of H3K4me3 are regulated, how H3K4me3 contributes to the regulation of specific phases of transcription such as RNA polymerase II initiation, pause-release, heterogeneity, and consistency. The conclusion from these studies is that H3K4me3…
Citation impact
- FWCI
- 28.74
- Percentile
- 100%
- References
- 156
Authors
2Topics & keywords
- H3K4me3
- Biology
- Epigenetics
- Histone
- Regulation of gene expression
- Transcription (linguistics)
- Genetics
- Gene expression
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