A Double Network Composite Hydrogel with Self-Regulating Cu 2+ /Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of wound healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release of cupric ions and luteolin and modulates mechanical properties to promote chronic wound healing. The double network hydrogel, GSC, is fabricated through photo-cross-linking of gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ release to eliminate bacteria in the acidic pH environment during inflammation and reduces the hydrogel’s mechanical strength to minimize tissue trauma during early dressing changes. On the other hand, GSC…

• DO
  Department of Science and Technology of Sichuan Province

  Awards: 2024NSFSC0605, 2022NSFSC1939