Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota
Technical University of Denmark · University of Copenhagen
Abstract
Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is directed towards indole, associated with chronic kidney disease, or towards protective indolelactic acid (ILA) and indolepropionic acid (IPA) is unclear. Here we used in vitro culturing and animal experiments to assess gut microbial competition for tryptophan and the resulting metabolites in a controlled three-species defined community and in complex undefined human faecal communities. The generation of specific tryptophan-derived metabolites was not predominantly determined by the abundance of tryptophan-metabolizing…
Citation impact
- FWCI
- 43.21
- Percentile
- 100%
- References
- 68
Authors
9Topics & keywords
- Tryptophan
- Tryptophanase
- Biology
- Biochemistry
- Gut flora
- Microbiology
- Indole test
- Metabolism