GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans
Seoul National University · Southwestern Medical Center · +6 more institutions
Abstract
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMH GLP-1R neurons caused satiation. Calcium imaging demonstrated that these neurons are actively involved in encoding preingestive satiation. GLP-1RA administration increased the activity of DMH GLP-1R neurons selectively during eating behavior.…
Citation impact
- FWCI
- 29.58
- Percentile
- 100%
- References
- 48
Authors
23- KSKyu Sik Kim
Seoul National University
- KSKyu Sik KimCorresponding
Seoul National University
- JSJoon Seok ParkCorresponding
Seoul National University, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- EHEun‐Sang HwangCorresponding
Seoul National University, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- MPMin-Jung Park
Seoul National University
Topics & keywords
- Electronic circuit
- Neuroscience
- Biology
- Internal medicine
- Psychology
- Medicine
- Engineering
- Electrical engineering
- Zero hunger
Funding
- NRNational Research Foundation
- KHKorea Health Industry Development InstituteAward: HI22C1060
- NRNational Research Foundation of KoreaAwards: 2021R1A6A3A14044733, 2018R1A5A2025964, NRF-2018R1A5A2025964
- NINational Institutes of HealthAwards: GM140854, R01 DK119169
- NINational Institute of General Medical Sciences
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAward: R01 DK119169