Multifaceted Carbonized Metal–Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy

Zhao, Chen; Tang, Xiaoying; Chen, Xiaoyuan; Jiang, Zhenqi

doi:10.1021/acsnano.4c04022

articleACS NanoJun 28, 2024Closed access

Multifaceted Carbonized Metal–Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy

CZChen Zhao XTXiaoying Tang XCXiaoyuan Chen ZJZhenqi Jiang

Beijing Institute of Technology · National University of Singapore · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The discovery of cuproptosis, a copper-dependent mechanism of programmed cell death, has provided a way for cancer treatment. However, cuproptosis has inherent limitations, including potential cellular harm, the lack of targeting, and insufficient efficacy as a standalone treatment. Therefore, exogenously controlled combination treatments have emerged as key strategies for cuproptosis-based oncotherapy. In this study, a Cu2–xSe@cMOF nanoplatform was constructed for combined sonodynamic/cuproptosis/gas therapy. This platform enabled precise cancer cotreatment, with external control allowing the selective induction of cuproptosis in cancer cells. This approach effectively prevented cancer metastasis and…

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122

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FWCI: 20.37
Percentile: 100%
References: 54

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Topics & keywords

Topics

Keywords

Cancer
Cancer therapy
Metal-organic framework
Immune checkpoint
Materials science
Cancer research
Nanotechnology
Carbonization

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