NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders

Ramachandran, Rajath; Manan, Abdul; Kim, Jei; Choi, Sangdun

doi:10.1038/s12276-024-01261-8

reviewExperimental & Molecular MedicineJul 1, 2024GOLD OA

NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders

RRRajath Ramachandran AMAbdul Manan JKJei Kim SCSangdun Choi

Ajou University

PubMed

Indexed incrossrefdoajpubmed

Abstract

Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body's defense mechanisms are detected, the innate immune system takes the lead. However, an excessive inflammatory response can lead to the production of high concentrations of cytotoxic molecules, resulting in tissue damage. Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 has a wide range of recognition mechanisms that streamline immune activation and eliminate pathogens. These cytosolic…

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Topics & keywords

Topics

Keywords

Inflammasome
Innate immune system
Proinflammatory cytokine
Pyroptosis
Immunology
Immune system
Pattern recognition receptor
Chemokine

UN Sustainable Development Goals

Good health and well-being

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