reviewExperimental & Molecular MedicineJul 1, 2024GOLD OA

Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology

LTLucie ThorelMPMarion PerréardRFRomane FlorentJDJordane DivouxSCSophia Coffy

Inserm · Centre François Baclesse · +13 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively revolutionized three-dimensional cell culture in oncology. PDTO can be grown from patient tumor samples with high efficiency and faithfully recapitulates the histological and molecular characteristics of the original tumor. Therefore, PDTOs can serve as invaluable tools in oncology research, and their translation to clinical practice is exciting for the future of precision medicine in oncology. In this review, we provide an overview of methods for establishing PDTOs and their various applications in cancer research, starting with basic research and ending with the…

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142
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FWCI
35.66
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100%
References
203
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Authors

11

Topics & keywords

Topics
Keywords
  • Precision oncology
  • Clinical Oncology
  • Precision medicine
  • Medicine
  • Oncology
  • Translational research
  • Organoid
  • Cancer Medicine
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