A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells

Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, the immune privilege phenomenon, coupled with the generally low immunogenicity of vaccines, frequently hampers the presence of lymphocytes within brain tumors, particularly in brain tumors. In this study, the membrane-disrupted polymer-wrapped CuS nanoflakes that can penetrate delivery to deep brain tumors via releasing the cell–cell interactions, facilitating the near-infrared II (NIR II) photothermal therapy, and detaining dendritic cells for a self-cascading immunotherapy are developed. By convection-enhanced delivery, membrane-disrupted amphiphilic polymer micelles…

• CG
  Chang Gung Memorial Hospital

  Award: CORPG3L0061
• CG
  Chang Gung Medical Foundation
• NH
  National Health Research Institutes

  Awards: EX112-11111EI, NHRI-EX112-11111EI
• NT
  National Tsing Hua University

  Awards: 111F7MELE1, 111Q2715E1
• NS
  National Science and Technology Council

  Awards: NSTC 111-2321-B-A49-009, NSTC 112-2326-B-007-006, 111-2321-B-A49-009, MOST 111-2636-E-007-021, NSTC 112-2314-B-007-005-MY3, MOST-110-2634-F-007-025, NSTC 112-2321-B-007-003, MOST 111-2636-B-007-007, NSTC 112-2321-B-A49-007