A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy
University of Antwerp · Flemish Institute for Technological Research · +1 more institution
Abstract
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste disposal vesicle but are an essential part of an intercellular communication system. Besides the use of EVs in biomarker studies and diagnostics, the potential of EV-therapeutics has been seen by many. They provide unique properties for disease therapy, including strong immune-modulatory actions, the possibility of engineering, low immunogenicity, and the capability of crossing biological barriers. Proof-of-concept of EV-therapeutics for various pathologies has been achieved in preclinical studies. However, clinical trials with EVs have only been emerging slowly. Here, we aim to provide a comprehensive overview of the…
Citation impact
- FWCI
- 22.87
- Percentile
- 100%
- References
- 69
Authors
5- MVMats Van DelenCorresponding
University of Antwerp, Flemish Institute for Technological Research
- JDJudith Derdelinckx
University of Antwerp, Antwerp University Hospital
- KWKristien Wouters
Antwerp University Hospital
- INInge Nelissen
Flemish Institute for Technological Research
- NCNathalie Cools
University of Antwerp, Antwerp University Hospital
Topics & keywords
- Extracellular vesicles
- Meta-analysis
- Clinical trial
- Medicine
- Extracellular vesicle
- Internal medicine
- Microvesicles
- Chemistry