Exosome for mRNA delivery: strategies and therapeutic applications

Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous clinical applications in treating central nervous system disorders, tumors, COVID-19, and other diseases. mRNA therapies must be encapsulated into safe, stable, and effective delivery vehicles to preserve the cargo from degradation and prevent immunogenicity. Exosomes have gained growing attention in mRNA delivery because of their good biocompatibility, low immunogenicity, small size, unique capacity to traverse physiological barriers, and cell-specific tropism. Moreover, these exosomes can be engineered to utilize the natural carriers to target specific cells or tissues. This targeted approach will enhance the efficacy and…

• NN
  National Natural Science Foundation of China

  Awards: 2019B030335001, No. 81972116, SZGSP013, 81972116, XMHT20220104028
• MO
  Ministry of Science and Technology of the People's Republic of China
• SU
  Shenzhen University

  Award: 2023YG014
• DA
  Development and Reform Commission of Shenzhen Municipality
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2023A1515011936