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RETRACTED: Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application
Yenepoya University · IMU University · +3 more institutions
Abstract
The microbiota-gut-brain axis (MGBA) represents a sophisticated communication network between the brain and the gut, involving immunological, endocrinological, and neural mediators. This bidirectional interaction is facilitated through the vagus nerve, sympathetic and parasympathetic fibers, and is regulated by the hypothalamic-pituitary-adrenal (HPA) axis. Evidence shows that alterations in gut microbiota composition, or dysbiosis, significantly impact neurological disorders (NDs) like anxiety, depression, autism, Parkinson's disease (PD), and Alzheimer's disease (AD). Dysbiosis can affect the central nervous system (CNS) via neuroinflammation and microglial activation, highlighting the importance of the…
Citation impact
- FWCI
- 35.41
- Percentile
- 100%
- References
- 171
Authors
9Topics & keywords
- Gut–brain axis
- Synbiotics
- Neuroinflammation
- Dysbiosis
- Gut flora
- Neuroscience
- Neuroprotection
- Autism
- Good health and well-being