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reviewHeliyonJul 1, 2024GOLD OA

RETRACTED: Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application

Yenepoya University · IMU University · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The microbiota-gut-brain axis (MGBA) represents a sophisticated communication network between the brain and the gut, involving immunological, endocrinological, and neural mediators. This bidirectional interaction is facilitated through the vagus nerve, sympathetic and parasympathetic fibers, and is regulated by the hypothalamic-pituitary-adrenal (HPA) axis. Evidence shows that alterations in gut microbiota composition, or dysbiosis, significantly impact neurological disorders (NDs) like anxiety, depression, autism, Parkinson's disease (PD), and Alzheimer's disease (AD). Dysbiosis can affect the central nervous system (CNS) via neuroinflammation and microglial activation, highlighting the importance of the…

Citation impact

168
total citations
FWCI
35.41
Percentile
100%
References
171
Citations per year

Authors

9

Topics & keywords

Keywords
  • Gut–brain axis
  • Synbiotics
  • Neuroinflammation
  • Dysbiosis
  • Gut flora
  • Neuroscience
  • Neuroprotection
  • Autism
UN Sustainable Development Goals
  • Good health and well-being
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