reviewAlzheimer s & DementiaJul 5, 2024HYBRID OA

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease

EMEider M. Arenaza‐UrquijoRBRory BoyleKBKaitlin B. CasalettoKJKaarin J. AnsteyCVClara Vila‐Castelar

Universitat Pompeu Fabra · Barcelona Institute for Global Health · +26 more institutions

PubMed
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Abstract

Sex and gender-biological and social constructs-significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience and resistance mechanisms explaining maintained cognitive function and reduced pathology accumulation in aging and AD. In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex- and gender-specific…

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175
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FWCI
58.66
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100%
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279
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Authors

27

Topics & keywords

Topics
Keywords
  • Cognition
  • Psychology
  • Disease
  • Psychological resilience
  • Biological sex
  • Developmental psychology
  • Brain Structure and Function
  • Cognitive decline
UN Sustainable Development Goals
  • Gender equality
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