Emerging Therapeutic Strategies to Overcome Drug Resistance in Cancer Cells

The rise of drug resistance in cancer cells presents a formidable challenge in modern oncology, necessitating the exploration of innovative therapeutic strategies. This review investigates the latest advancements in overcoming drug resistance mechanisms employed by cancer cells, focusing on emerging therapeutic modalities. The intricate molecular insights into drug resistance, including genetic mutations, efflux pumps, altered signaling pathways, and microenvironmental influences, are discussed. Furthermore, the promising avenues offered by targeted therapies, combination treatments, immunotherapies, and precision medicine approaches are highlighted. Specifically, the synergistic effects of combining…

• UD
  U.S. Department of Defense

  Awards: P30CA33572, HT9425-23-1-0581, W81XWH, W81XWH-22-1-0331
• BR
  Beckman Research Institute, City of Hope
• CO
  City of Hope
• NI
  National Institutes of Health

  Awards: W81XWH, P30CA33572
• NC
  National Cancer Institute

  Award: P30CA33572