Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Ekanem, Emmanuel; Neužil, Petr; Reichlin, Tobias; Kautzner, J; Voort, Pepijn van der; Jaı̈s, Pierre; Chierchia, Gian‐Battista; Bulava, Alan; Blaauw, Yuri; Skála, Tomáš; Fiala, Martin; Duytschaever, Mattias; Széplaki, Gábor; Schmidt, Boris; Massoullié, Grégoire; Neven, Kars; Thomas, Olivier; Vijgen, Johan; Gandjbakhch, Estelle; Scherr, Daniel; Johannessen, Arne; Keane, David; Bovéda, Serge; Maury, Philippe; García-Bolao, Ignacio; Anić, Ante; Hansen, Peter S.; Raczka, Franck; Lepillier, Antoine; Guyomar, Yves; Gupta, Dhiraj; Opstal, Jurren M. van; Defaye, Pascal; Sticherling, Christian; Sommer, Philipp; Kučera, Pavel; Osca, Joaquín; Tabrizi, Fariborz; Roux, Antoine; Gramlich, Michael W.; Bianchi, Stefano; Adragão, Pedro; Solimene, Francesco; Tondo, Claudio; Russo, Antonio Dello; Schreieck, Jürgen; Luik, Armin; Rana, Obaida R.; Frommeyer, Gerrit; Anselme, Frédéric; Kreis, Ingo; Rosso, Raphaël; Metzner, Andreas; Gellér, László; Baldinger, Samuel H.; Ferrero, Ángel; Willems, Stephan; Goette, Andreas; Mellor, Greg; Mathew, Shibu; Szumowski, Łukasz; Tilz, Roland Richard; Iacopino, Saverio; Jacobsen, Peter Karl; George, Andrikopoulos; Osmančík, Pavel; Spitzer, Stefan G.; Balasubramaniam, Richard; Parwani, Abdul Shokor; Deneke, Thomas; Główniak, Andrzej; Rossillo, Antonio; Pürerfellner, Helmut; Duncker, David; Reil, P; Arentz, Thomas; Steven, Daniel; Olalla, Juan J.; Jong, Jonas S.S.G. de; Wakili, Reza; Abbey, Sélim; Timo, Gottschling; Asso, Antonio; Wong, Tom; Pierre, Bertrand; Ewertsen, Niels Christian; Bergau, Leonard; Lozano-Granero, Cristina; Rivero, Maximo; Breitenstein, Alexander; Inkovaara, J; Fareh, Samir; Lațcu, Decebal Gabriel; Linz, Dominik; Müller, Patrick; Ramos‐Maqueda, Javier; Beiert, Thomas; Themistoclakis, Sakis; Meininghaus, Dirk Große; Stix, G; Tzeis, Stylianos; Baran, Jakub; Almroth, Henrik; Muñoz, Daniel; Sousa, João de; Efremidis, Michalis; Balsam, Paweł; Petrů, Jan; Küffer, Thomas; Peichl, Petr; Dekker, Lukas; Rocca, Domenico G. Della; Moravec, Ondřej; Funasako, Moritoshi; Knecht, Sébastien; Jauvert, Gael; Chun, Julian; Eschalier, Romain; Füting, Anna; Zhao, Alexandre; Koopman, Pieter; Laredo, Mikaël; Manninger, Martin; Hansen, Jim; O’Hare, Daniel; Rollin, Anne; Jurišić, Zrinka; Fink, Thomas; Chaumont, Corentin; Rillig, Andreas; Gunawerdene, Melanie; Martin, Claire; Kirstein, Bettina; Nentwich, Karin; Lehrmann, Heiko; Sultan, Arian; Bohnen, Jan; Turagam, Mohit K.; Reddy, Vivek Y.

doi:10.1038/s41591-024-03114-3

articleNature MedicineJul 1, 2024HYBRID OA

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

EEEmmanuel Ekanem PNPetr Neužil TRTobias Reichlin JKJ Kautzner PVPepijn van der Voort

Winchester Medical Center · Icahn School of Medicine at Mount Sinai · +123 more institutions

PubMed

Indexed incrossrefdatacitepubmed

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic…

Citation impact

388

total citations

FWCI: 144.70
Percentile: 100%
References: 49

Citations per year

Authors

139

Topics & keywords

Topics

Keywords

Atrial fibrillation
Medicine
Cardiology
Ablation
Internal medicine

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.