Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses. In this review, we provide an update of Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases. The Wnt proteins, receptors, activators, inhibitors, and the crosstalk of Wnt signaling pathways with other signaling pathways are summarized and discussed. We mainly review Wnt signaling functions in bone formation, homeostasis, and related…

• NN
  National Natural Science Foundation of China

  Awards: 32371371, 81772017, 82072106
• NI
  National Institutes of Health

  Awards: AR-070135, AG-056438
• NS
  Natural Science Basic Research Program of Shaanxi Province
• NI
  National Institute on Aging

  Award: AG056438
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: AR074954, AR075735, AR070135
• NI
  National Institute of Dental and Craniofacial Research

  Awards: DE023813, DE028264