Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials
Taipei Medical University · China Medical University · +2 more institutions
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Abstract
Abstract Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.
Citation impact
185
total citations
- FWCI
- 38.98
- Percentile
- 100%
- References
- 120
Citations per year
Authors
4Topics & keywords
Topics
Keywords
- Microvesicles
- Exosome
- Extracellular vesicles
- Context (archaeology)
- Function (biology)
- Nucleic acid
- Drug delivery
- Computational biology
UN Sustainable Development Goals
- Good health and well-being
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Funding
- NSNational Science and Technology CouncilAward: (NSTC 112-2320-B-038-020
- MOMinistry of Science and TechnologyAward: MOST 110-2320-B-038-070
- MOMinistry of Health and WelfareAwards: MOHW112-TDU-B-222-014013, MOHW113-TDU-B-222-134013
- NSNational Science and Technology CouncilAwards: 113-2634-F-039-001, NSTC 113-2634-F-039-001