reviewChemical ScienceJan 1, 2024DIAMOND OA

Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

XWXia WangJPJinlei PengCMChi MengFFFude Feng

Nanjing University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have been made to improve the PDT effect in terms of safety and efficiency. In this review, we highlight recent advances in innovative strategies for enhanced PDT, including (1) the development of novel radicals, (2) design of activatable photosensitizers based on the TME and light, and (3) photocatalytic NADH oxidation to damage the mitochondrial electron transport chain. Additionally, the new mechanisms for PDT are also presented as an inspiration for the design of novel PSs. Finally, we discuss the current challenges…

Citation impact

107
total citations
FWCI
17.98
Percentile
100%
References
155
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Photodynamic therapy
  • Cancer therapy
  • Nanotechnology
  • Computer science
  • Cancer treatment
  • Risk analysis (engineering)
  • Cancer
  • Medicine
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